Are Soy Isoflavones an alternative to Clomid for twins?

Soy isoflavones ( SI) is a supplement used in women’s health. It is used to treat unpleasant symptoms of menopause, promotes maintenance of bone health, and hot flash reduction. Its taken by mouth by tablet, and also comes in a topical form.

As discussed on internet support forums, for those women looking for a natural fertility boost, Soy isoflavones (SI) can be an alternative to the prescription fertility medication Clomid.

Derived from plant compounds, Soy Isoflavones is a supplement that’s presumed to have weak effects on the estrogen receptors in the body. Soy isoflavones are used by women seeking an alternative to Clomid.

In theory, taking soy isoflavone increases production of follicles. With an increase in follicles, the chances of to two or more fertilized eggs for a multiple gestation pregnancy may be achieved.

SI is also used by women who have PCOS, and or anovulatory cycles and want to induce ovulation.

What is the proof, numbers of success, and scientific research?


For the most part, a lot of the information found about soy isoflavone as an alternative to Clomid is anecdotal, internet forum opinions, and from individual experience. However the US national library of medicine has some clinical research on the estrogenic effects of taking high dose soy isoflavone supplements.

According to the US national library of medicine, ovarian function and fertility may be negativity altered by high levels of soy. The reproductive system relies on hormones for proper function. High levels of photestrogens may interfere with this function and alter signalizing for ovulation. Similarly as the way estrogen’s in birth control alter function to natural ovulation.

Moreover, taking exogenous levels of the supplement soy isoflavone could negatively impact fertility if the estrogenic effects are high enough.

Taking high dose soy isoflavone for long periods of time suppresses the luteinizing hormone(LH) surge that signals the body to ovulate. Thus, the unfounded idea behind taking soy isoflavone to increase the chances of conceiving twins is that the sudden drop in estrogen will signal hyperovulation. This is however just an hypothesis.

Soy Isoflavone protocol when trying to conceive twins

From a medical perspective, perfectly healthy women trying to conceive should not be aiming for multiples . A single healthy baby is less dangerous than multiples. More than a single gestation may put your own life and the babies life at risk. With that said, if interested in a protocol, below are ways SI’s taken as an alternative to Clomid.

soy isoflavones alternative clomid

Soy Isoflavone Protocol for Twins 1

Soy isoflavones 100mg -200mg taken in the morning CD 1-5 with a maximum dose of 200mg

CD 1-5 = you produce more eggs, and ovulate sooner, with a stronger ovulation

Soy Isoflavone Protocol for Twins 2

Soy isoflavones 100mg-200mg taken in the morning CD 2-6 with a maximum dose of 200mg

CD 2-6 = you produce more eggs that usual. Eggs may be more mature, and ovulation will be slightly more strong than 1-5

Soy Isoflavone Protocol for Twins 3

Soy isoflavones 100mg-200mg taken in the morning CD 3-7 with a maximum dose of 200mg

CD 3-7 = The best all around choice, a few more eggs, and all eggs will be strong & mature, and ovulation will be a lot stronger than 1-5

Whatever protocol you decide to do, the latest you should start taking Soy isoflavones is CD5. Taking it longer than 5 days will have negative effects on your fertility.

Soy isoflavone alternative to clomid
Soy Isoflavone

Things to note about Soy Isoflavones

From the most compelling evidence, the earlier in your cycle you take soy isoflavone, the higher your chance of releasing multiple eggs.

Most women choose the middle protocol (cycle days 3-7). This allows time for a strong and healthy egg to develop without erasing the chance of a second egg developing.

Ovarian function is complex and involves the ovary, hypothalamus and pituitary gland. Its a solidly regulated positive and negative feedback loop cycle. Interference of this balance with soy isoflavones can have very powerful effects on the ability to alter fertility and ovulation.



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